Review of Bacillus anthracis (Anthrax) studies for dose-response modeling to estimate risk
Citation:
U.S. EPA. Review of Bacillus anthracis (Anthrax) studies for dose-response modeling to estimate risk. U.S. Environmental Protection Agency, Washington, DC, EPA/600/S-12/681, 2012.
Impact/Purpose:
The primary purpose of this evaluation was to identify published, open source dose-response data sets and provide a preliminary assessment of their data usability for modeling low dose Bacillus anthracis exposures. This technical brief summarizes a very large scientific report that reviews available data to conduct a human health risk assessment for Bacillus anthracis.
Description:
This technical brief identifies current challenges in the development of a Bacillus anthracis dose-response relationship specifically for low dose exposures, summarizes available dose-response data sets for inhalation exposures in commonly used animal models and observational data gathered from human epidemiological studies, and assesses the usability of the identified dose-response data sets for modeling low dose exposures.